2019's abstract booklet can be downloaded here
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Inhalt
Wednesday, 4 September 2019 | |
16:00 - 17:00 | Registration |
Keynote Lectures and Festive OpeningChair: Ursula Ravens (IEKM, Freiburg) | |
17:00 - 17:15 | Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the IEKM) Welcome addresses |
17:15 - 18:00 | Donald M. Bers (UC Davis Health) Orchestrating nanodomain signals for the integrated cardiac fight-or-flight response |
18:00 - 18:45 | Thomas Eschenhagen (UKE Hamburg) Cardiac mechanics matters: models and muddles |
18:45 - 19:00 | Wrap-up |
19:00 - 21:00 | Reception Prometheus Hall |
Thursday, 5 September 2019 | |
09:00 - ... | Registration |
09:15 - 09:30 | Remi Peyronnet (IEKM, Freiburg) Greeting |
Session 1: Mechano-Sensitive Ion ChannelsChair: Frederick Sachs (SUNY Buffalo) | |
09:30 - 10:00 | Jack Rubinstein (Cincinatti) TRP channels as regulators of cardiac hypertrophy |
10:00 - 10:30 | Marc Freichel (Heidelberg) Regulating pathological cardiac remodeling via TRPC channels and new players in endo-lysosomal Ca2+ signaling |
10:30 - 11:00 | Niels Decher (Marburg) Arrhythmogenic mutation in human TREK-1: conversion of a SAK to a hypersensitive SAC |
| Coffee and Posters |
11:30 - 12:00 | Wei-Zheng Zeng (Scripps Research, La Jolla) Piezo channels mediate baroreceptor mechano-transdurction and the baroreflex |
12:00 - 12:30 | Boris Martinac (Sydney) The role of Piezo1 in cardiac hypertrophy |
| Lunch and Posters |
Session 2: Stretch Effects on other Molecular MechanismsChair: Gudrun Antoons (Maastricht) | |
14:00 - 14:30 | Thomas Iskratsch (London) Roles of muscle and non-muscle myosin contractions |
14:30 - 15:00 | Farah Sheikh (UCSD) Mechanical modulation of cell junctions: relevance for cardiac electrophysiology |
15:00 - 15:30 | Michele Miragoli (Parma) Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders |
| Tea and Posters |
16:00 - 16:30 | Gentaro Iribe (Okayama) Role of nucleotide signalling in mechano-sensitive responses of organelle and cellular mechanisms |
16:30 - 17:00 | Kenneth Campbell (Kentucky) Length-dependent activation in human material |
17:00 - 17:15 | Jia Li (Poster 09) Stretch Synchronizes Sarcomere Shortening in Cardiomyocytes: Implications for Frank-Starling Mechanism |
17:15 - 17:30 | Elaheh Zare-Eelanjegh (Poster 08) Fluid Force Microscopy for Micro-Manipulation of Single Cardiac Muscle Cells |
Poster Session | |
17:30 - 19:30 | Posters with refreshments, and nibbles, and more… |
Friday, 6 September 2019 | |
Session 3: Methods and Concepts for Quantifying Cardiac MechanicsChair: Delphine Dean (Clemson) | |
09:00 - 09:30
| Michael Gotthardt (MDC, Berlin) A Visual and Biomechanical Approach to Sarcomere Dynamics |
09:30 - 10:00
| Ramona Emig (IEKM, Freiburg) Hydrogels with Light-Tunable Stiffness as a Novel Research Tool for Cardiac Mechanobiology |
10:00 - 10:30
| Ye Chen-Izu (UC Davis) Mechanical Load Effects on Cardiomyocyte Action Potential and Arrhythmogenic Activities |
| Coffee and Posters |
11:00 - 11:30
| Periklis Pantazis (London) GenEPi:Piezo1-Based Fluorescent Reporter for Visualizing Mechanical Stimuli with High Spatiotemporal Resolution |
11:30 - 12:00
| Leonardo Sacconi (Florence) Random Access Confocal Microscopy for Cardiac Research
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| Lunch and Posters |
Session 4: Cell and Tissue Level MECChair: Alex Quinn (Halifax) | |
13:30 - 14:00 | Anastasia Khokhlova (Yekaterinburg) Transmural Differences in Single Cardiomyocyte Electro-Mechanics |
14:00 - 14:30 | Takuro Tomita (Matsumoto) Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness |
14:30 - 15:00 | Diane Fatkin (Sydney) Atrial Endocardial TRPC6 Channels and Load-Dependent Endocardial/Myocardial Cross-Talk |
| Tea and Posters |
15:30 - 16:00 | Kate Herum (UCSD) Mechanical Regulation of Cardiac Fibroblast Phenotypes |
16:30 - 17:00 | Ming Guo (MIT) Mechanics of Cell Matrix Interface in 3D |
17:00 - 17:15 | Breanne Cameron (Poster 25) Cellular Mechanisms of Mechano-Arrhythmogenicity During Acute Ischemia |
17:15 - 17:30 | Ana Simon-Chica (Poster 06) Stretch-Activated Channels Modulate the Activity of Resident and Bone Marrow Derived Cardiac Macrophages |
18:00 - ... | Optional: Guided walking tour of historic Freiburg or Tour of IEKM |
Saturday, 7 September 2019 | |
Session 5: MEC & Arrhythmias: Organ LevelChair: Andrew McCulloch (UCSD) | |
09:00 - 09:30
| Eilidh MacDonald (Halifax) MEC in Zebrafish: Utility and Limitations for pacemaker studies
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09:30 - 10:00
| Callum Johnston (IEKM, Freiburg) Opto-Acoustic Imaging of 3D Cardiac Electrophysiology
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10:00 - 10:30
| Denis Loiselle (Auckland) Frank-Starling reloaded |
| Coffee and Posters |
11:00 - 11:30
| Jeffrey Holmes (Virginia) Mechanics, Dynamics and Therapeutic Modification of Myocardial Infarct Scar |
11:30 - 12:00
| William Louch (Oslo) Understanding Plasticity of Dyadic Structure and Function
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| Lunch and Posters |
Session 6: MEC & Arrhythmias: Translational AspectsChair: Crystal Ripplinger (UC Davis) | |
13:00 - 13:30 | Paul Volders (Maastricht) Neuro-Mechanical Cross-Talk in Proarrhythmia of Drug-Induced Long-QT Syndrome |
13:30 - 14:00 | Pier Lambiase (London) Structural Remodeling and Conduction Velocity Dynamics in Human Left Atrium: Relation with Re-entrant Mechanisms Sustaining AF |
14:00 - 14:30 | Esther Pueyo (Zaragoza) The interplay of Autonomic and Mechanical Modulation of Ventricular Repolarization in Human |
| Tea and Posters |
Closing SessionChair: Peter Kohl (IEKM), Mark Marshall (Medtronic) | |
15:00 - 15:15 | Donald M. Bers (UC Davis Health) What we've learned and what should we focus on next in terms of mechanisms |
15:15 - 15:30 | Thomas Eschenhagen (UKE Hamburg) What we've learned and what should we focus on next in terms of clinical relevance |
15:30 - 16:00 | Discussion, Participant feedback |
17:30 - 00:00 | Meeting Dinner at Peterhofkeller |
17:30 - 18:00 | Reception |
18:00 - 18:15 | Poster Awards |
18:15 | Dinner |
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