Wednesday, 4 September 2019 | |
16:00 - 17:00 | Registration |
Keynote Lectures and Festive OpeningChair: Ursula Ravens (Institute for Experimental Cardiovascular Medicine (IEKM), Freiburg) | |
17:00 - 17:15 | Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the IEKM) Welcome addresses |
17:15 - 18:00 | Donald M. Bers (UC Davis Health) Cardiac electro-mechanical cross-talk: what's new? |
18:00 - 18:45 | Thomas Eschenhagen (UKE Hamburg) Cardiac mechanics matters: models and muddles |
18:45 - 19:00 | Wrap-up |
19:00 - 21:00 | Reception Prometheus Hall |
Thursday, 5 September 2019 | |
09:00 - ... | Registration |
09:15 - 09:30 | Remi Peyronnet (IEKM, Freiburg) MEC2019 |
Session 1: Mechano-Sensitive Ion ChannelsChair: Boris Martinac (Sydney) | |
09:30 - 10:00 | Wei-Zheng Zeng (Scripps Research, La Jolla) Piezo and arterial baro-reception |
10:00 - 10:30 | Jack Rubinstein (Cincinatti) TRP channels as regulators of cardiac hypertrophy |
10:30 - 11:00 | Marc Freichel (Heidelberg) Regulating pathological cardiac remodeling via TRPC channels and new players in endo-lysosomal Ca2+ signaling |
| Coffee and Posters |
11:30 - 12:00 | Niels Decher (Marburg) Arrhythmogenic mutation in human TREK-1: conversion of a SAK to a hypersensitive SAC |
12:00 - 12:30 | Gentaro Iribe (Okayama) Role of nucleotide signalling in mechano-sensitive responses of organelle and cellular mechanisms |
| Lunch and Posters |
Session 2: Stretch Effects on other Molecular MechanismsChair: Gudrun Antoons (Maastricht) | |
14:00 - 14:30 | Thomas Iskratsch (London) Cardiomyocyte - ECM interactions: roles of muscle and non-muscle myosin contractions |
14:30 - 15:00 | Farah Sheikh (UCSD) Mechanical modulation of cell junctions: relevance for cardiac electrophysiology |
15:00 - 15:30 | Michele Miragoli (Parma) Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders |
| Tea and Posters |
16:00 - 16:30 | Michael Gotthardt (MDC, Berlin) A Visual and Biomechanical Approach to Sarcomere Dynamics |
16:30 - 17:00 | Kenneth Campbell (Kentucky) Length-dependent activation in human material |
17:00 - 17:30 | Two presentations selected from abstracts (2 x 10+5 min) |
Poster Session | |
17:30 - 19:30 | Posters with refreshments, and nibbles, and more… |
Friday, 6 September 2019 | |
Session 3: Methods and Concepts for Quantifying Cardiac MechanicsChair: Delphine Dean (Clemson) | |
09:00 - 09:30 | Ramona Emig (IEKM, Freiburg) Light-tuneable hydrogels |
09:30 - 10:00 | Ye Chen-Izu (UC Davis) Mechanical load effects on AP, [Ca2+]i, and contraction revealed using patch-clamp-in-gel |
10:00 - 10:30 | Periklis Pantazis (London) Piezo1-based fluorescent reporter for visualizing mechanical stimuli |
| Coffee and Posters |
11:00 - 11:30 | TBC Stretch-induced compliance: a novel adaptive biological mechanism following acute cardiac load |
11:30 - 12:00 | Leonardo Sacconi (Florence) Random Access Confocal Microscopy for cardiac research |
| Lunch and Posters |
Session 4: Cell and Tissue Level MECChair: Alex Quinn (Halifax) | |
13:30 - 14:00 | Anastasia Khokhlova (Yekaterinburg) Transmural differences in cardiac electro-mechanics |
14:00 - 14:30 | Takuro Tomita (Matsumoto) TRPC3-Nox2 functional coupling regulates cardiac elasticity |
14:30 - 15:00 | Diane Fatkin (Sydney) Atrial endocardial TRPC channels and load-dependent endocardial/myocardial cross-talk |
| Tea and Posters |
15:30 - 16:00 | Kate Herum (UCSD) Mechanical regulation of cardiac fibroblast phenotypes |
16:30 - 17:00 | Ming Guo (MIT) Cell contraction induces long-ranged stress changes in the extracellular matrix |
17:00 - 17:30 | Two presentations selected from abstracts (2 x 10+5 min) |
18:00 - ... | Optional: Guided walking tour of historic Freiburg or Tour of IEKM |
Saturday, 7 September 2019 | |
Session 5: MEC & Arrhythmias: Organ LevelChair: Andrew McCulloch (UCSD) | |
09:00 - 09:30 | Eilidh MacDonald (Halifax) MEC in Zebrafish: Utility and Limitations for pacemaker studies |
09:30 - 10:00 | Callum Johnston (IEKM, Freiburg) Opto-Acoustic Imaging of 3D Cardiac Electrophysiology |
10:00 - 10:30 | Denis Loiselle (Auckland) Frank-Starling reloaded |
| Coffee and Posters |
11:00 - 11:30 | Jeffrey Holmes (Virginia) Mechanics, dynamics and therapeutic modification of myocardial infarct scar |
11:30 - 12:00 | William Louch (Oslo) Wall stress induced disturbance in cardiomyocyte ultrastructure |
| Lunch and Posters |
Session 6: MEC & Arrhythmias: Translational AspectsChair: Crystal Ripplinger (UC Davis) | |
13:00 - 13:30 | Paul Volders (Maastricht) Neuro-mechanical cross-talk in proarrhythmicity of drug-induced LQT syndrome |
13:30 - 14:00 | Pier Lambiase (London) Structural remodeling and conduction velocity dynamics in human left atrium: relation with reentrant mechanisms sustaining AF |
14:00 - 14:30 | Esther Pueyo (Zaragoza) The interplay of autonomic and mechanical modulation of ventricular repolarization in human |
| Tea and Posters |
Closing SessionChair: Peter Kohl (IEKM, Freiburg) | |
15:00 - 15:15 | Donald M. Bers (UC Davis Health) What we've learned and what should we focus on next in terms of mechanisms |
15:15 - 15:30 | Thomas Eschenhagen (UKE Hamburg) What we've learned and what should we focus on next in terms of clinical relevance |
15:30 - 16:00 | Discussion, Participant feedback |
17:30 - 00:00 | Meeting Dinner and Dance at Peterhofkeller |
17:30 - 18:00 | Reception |
18:00 - 18:15 | Poster Awards |
18:15 | Dinner |
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