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Inhalt

2019's abstract booklet can be downloaded here

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Wednesday, 4 September 2019

16:00 - 17:00

Registration

Keynote Lectures and Festive Opening

Chair: Ursula Ravens (IEKM, Freiburg)

17:00 - 17:15

Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the IEKM) Welcome addresses

17:15 - 18:00

Donald M. Bers (UC Davis Health) Orchestrating nanodomain signals for the integrated cardiac fight-or-flight response

18:00 - 18:45

Thomas Eschenhagen (UKE Hamburg) Cardiac mechanics matters: models and muddles

18:45 - 19:00

Wrap-up

19:00 - 21:00

Reception Prometheus Hall

Thursday, 5 September 2019

09:00 - ...

Registration

09:15 - 09:30

Remi Peyronnet (IEKM, Freiburg) Greeting

Session 1: Mechano-Sensitive Ion Channels

Chair: Remi Peyronnet (IEKM, Freiburg)

09:30 - 10:00

Jack Rubinstein (Cincinatti) TRP channels as regulators of cardiac hypertrophy

10:00 - 10:30

Marc Freichel (Heidelberg) Regulating pathological cardiac remodeling via TRPC channels and new players in endo-lysosomal Ca2+ signaling

10:30 - 11:00

Niels Decher (Marburg) Arrhythmogenic mutation in human TREK-1: conversion of a SAK to a hypersensitive SAC

 

Coffee and Posters

11:30 - 12:00

Frederick Sachs (SUNY Buffalo) Drug efficacy is a function of bilayer tension

12:00 - 12:30

Boris Martinac (Sydney) The role of Piezo1 in cardiac hypertrophy

 

Lunch and Posters

Session 2: Stretch Effects on other Molecular Mechanisms

Chair: Gudrun Antoons (Maastricht)

14:00 - 14:30

Thomas Iskratsch (London) Roles of muscle and non-muscle myosin contractions

14:30 - 15:00

Farah Sheikh (UCSD) Mechanical modulation of cell junctions: relevance for cardiac electrophysiology

15:00 - 15:30

Michele Miragoli (Parma) Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders

 

Tea and Posters

16:00 - 16:30

Gentaro Iribe (Okayama) Role of nucleotide signalling in mechano-sensitive responses of organelle and cellular mechanisms

16:30 - 17:00

Kenneth Campbell (Kentucky) Length-dependent activation in human material

17:00 - 17:15

Jia Li (Poster 09) Stretch Synchronizes Sarcomere Shortening in Cardiomyocytes: Implications for Frank-Starling Mechanism

17:15 - 17:30

Elaheh Zare-Eelanjegh (Poster 08) Fluid Force Microscopy for Micro-Manipulation of Single Cardiac Muscle Cells

Poster Session

17:30 - 19:30

Posters with refreshments, and nibbles, and more…

Friday, 6 September 2019

Session 3: Methods and Concepts for Quantifying Cardiac Mechanics

Chair: Delphine Dean (Clemson)

09:00 - 09:30

Michael Gotthardt (MDC, Berlin) A Visual and Biomechanical Approach to Sarcomere Dynamics

09:30 - 10:00

Ramona Emig (IEKM, Freiburg) Hydrogels with Light-Tunable Stiffness as a Novel Research Tool for Cardiac Mechanobiology

10:00 - 10:30

Ye Chen-Izu (UC Davis) Mechanical Load Effects on Cardiomyocyte Action Potential and Arrhythmogenic Activities

 

Coffee and Posters

11:00 - 11:30

Periklis Pantazis (London) GenEPi:Piezo1-Based Fluorescent Reporter for Visualizing Mechanical Stimuli with High Spatiotemporal Resolution

11:30 - 12:00

Leonardo Sacconi (Florence) Random Access Confocal Microscopy for Cardiac Research

 

Lunch and Posters

Session 4: Cell and Tissue Level MEC

Chair: Alex Quinn (Halifax)

13:30 - 14:00

Anastasia Khokhlova (Yekaterinburg) Transmural Differences in Single Cardiomyocyte Electro-Mechanics

14:00 - 14:30

Takuro Tomita (Matsumoto) Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness

14:30 - 15:00

Diane Fatkin (Sydney) Atrial Endocardial TRPC6 Channels and Load-Dependent Endocardial/Myocardial Cross-Talk

 

Tea and Posters

15:30 - 16:00

Kate Herum (UCSD) Mechanical Regulation of Cardiac Fibroblast Phenotypes

16:00 - 16:30

William Louch (Oslo) Understanding Plasticity of Dyadic Structure and Function

16:30 - 16:45

Breanne Cameron (Poster 25) Cellular Mechanisms of Mechano-Arrhythmogenicity During Acute Ischemia

16:45 - 17:00

Ana Simon-Chica (Poster 06) Stretch-Activated Channels Modulate the Activity of Resident and Bone Marrow Derived Cardiac Macrophages

17:00
17:30

Meeting Photo
Optional: Guided walking tour of historic Freiburg OR IEKM tour

Saturday, 7 September 2019

Session 5: MEC & Arrhythmias: Organ Level

Chair: Andrew McCulloch (UCSD)

09:00 - 09:30

Eilidh MacDonald (Halifax) MEC in Zebrafish: Utility and Limitations for pacemaker studies

09:30 - 10:00

Callum Johnston (IEKM, Freiburg) Opto-Acoustic Imaging of 3D Cardiac Electrophysiology

 

Coffee and Posters

10:30 - 11:00

Denis Loiselle (Auckland) Frank-Starling reloaded

11:00 - 11:30

Jeffrey Holmes (Virginia) Mechanics, Dynamics and Therapeutic Modification of Myocardial Infarct Scar

 

Lunch and Posters

Session 6: MEC & Arrhythmias: Translational Aspects

Chair: Crystal Ripplinger (UC Davis) 

13:00 - 13:30

Paul Volders (Maastricht) Neuro-Mechanical Cross-Talk in Proarrhythmia of Drug-Induced Long-QT Syndrome

13:30 - 14:00

Pier Lambiase (London) Structural Remodeling and Conduction Velocity Dynamics in Human Left Atrium: Relation with Re-entrant Mechanisms Sustaining AF

14:00 - 14:30

Esther Pueyo (Zaragoza) The interplay of Autonomic and Mechanical Modulation of Ventricular Repolarization in Human

 

Tea and Posters

Closing Session

Chair: Peter Kohl (IEKM), Mark Marshall (Medtronic)

15:00 - 15:15

Thomas Eschenhagen (UKE Hamburg) What we've learned and what should we focus on next in terms of clinical relevance

15:15 - 15:30

Donald M. Bers (UC Davis Health) What we've learned and what should we focus on next in terms of mechanisms

15:30 - 16:00

Discussion, Participant feedback

17:30 - 00:00

Meeting Dinner at Peterhofkeller

17:30 - 18:00

Reception

18:00 - 18:15

Poster Awards

18:15

Dinner

 


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