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Wednesday, 21 September 2016

Festive Opening of the Institute for Experimental Cardiovascular Medicine in Freiburg

Chair: Ursula Ravens (Freiburg)

17:00 – 17:45

Welcome addresses by:

Prof. Dr. Dr. h.c. Hans-Jochen Schiewer
Rector of the University of Freiburg, Chairman of the University Heart Centre Freiburg - Bad Krozingen

Prof. Dr. Dr. h.c. mult. J. Rüdiger Siewert
Chief Medical Director of the Medical Centre - University of Freiburg,
Medical Director of the University Heart Centre Freiburg - Bad Krozingen

Prof. Dr. Carola Hunte
Prodean of Research, Faculty of Medicine, University of Freiburg

Volker Kieber
Chairman of the Board of the Benedikt Kreutz Charitable Foundation Bad Krozingen

17:45 – 18:15

Kit Parker (Wyss Institute at Harvard University, Boston): Cardiovascular Engineering: Macro to Nano

18:15 – 18:45

Natalia Trayanova (Johns Hopkins University, Baltimore): Computational Cardiology: Nano to Macro

18:45 – 19:00

Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the Institute for Experimental Cardiovascular Medicine)

19:00 – 21:00

Reception

 

 

Thursday, 22 September 2016 

09:00 – 09:15

Peter Kohl (Freiburg): Greeting

09:15 – 09:30

Ursula Ravens (Freiburg): A tribute to Professor Max Lab 

Session 1: Stretch & Structure

Chair: Gentaro Iribe (Okayama)

09:30 – 10:00

Takashi Mikawa (San Francisco): Mechanical effects on developmental patterning of atrial conduction

10:00 – 10:30

Andrew McCulloch (San Diego): Stretch-induced changes in sarcolemmal organisation

 

Coffee and Posters

11:00 – 11:30

Eva Rog-Zielinska (London): Structural changes in cell membrane compartments during contraction and relaxation

11:30 – 12:00

Stephan Rohr (Bern): Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress

 

Lunch and Posters

Session 2: Mechano-Sensing Mechanisms in Striated Muscle 

Chair: Fred Sachs (Buffalo)

13:30 – 14:00

Malcolm Irving (KCL): Sarcomeric mechanosensing by myosin filaments: Frank-Starling reloaded?

14:00 – 14:30

Christopher Ward (Baltimore): Microtubules modulate mechanotransduction in heart muscle

14:30 – 15:00

Gudrun Antoons (Maastricht): Stretch-induced modulation of Ca2+ handling in atrial and ventricular myocytes

 

Tea and Posters

15:30 – 16:00

Pieter de Tombe (Chicago): Measuring organelle-entrapped calcium in ventricular sarcoplasmic reticulum: new methods and insights

16:00 – 16:30

Delphine Dean (Clemson): AFM-based mechanical characterisation of cardiac muscle cells 

Poster Session

16:30 – 19:00

With Refreshments, and Nibbles, and more…

 

 

Friday, 23 September 2016

Session 3: Quantifying & Classifying Mechanical Stimuli 

Chair: Veronique Meijborg (Amsterdam)

09:00 – 09:30

Boris Martinac (Sydney): Single molecule FRET to study pore size and opening mechanism of mechano-sensitive ion channels

09:30 – 10:00

Brenton Hoffman (Durham): Construction, imaging, and analysis of FRET-based tension sensors in living cells

10:00 – 10:30

Tomaso Zambelli (ETH Zurich): Force-controlled patch clamp of beating cardiac cells

 

Coffee and Posters

11:00 – 11:30

Dirk Trauner (Munich): Controlling Biological Pathways with Synthetic Photoswitches​

11:30 – 12:00

Stefan Luther (Göttingen): Simultaneous Mapping of Electrical and Mechanical Activity in the Non-Uncoupled Langendorff Heart​​ 

 

Lunch and Posters

Session 4: Stretch & Ion Handling 

Chair: Olga Solovyova (Ekaterinburg)

13:30 – 14:00

Mario Delmar (New York): Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

14:00 – 14:30

Stephane Sebille (Poitiers): Cardiac TRPV2 channels: role in mediating cardiac pathology

14:30 – 15:00

Thomas Suchyna (Buffalo): GsMTx-4: Mechanism of MSC inhibition and cardioprotective potential

 

Tea and Posters

15:30 – 16:00

Remi Peyronnet (Freiburg): Stretch-activated channels in human heart valves

16:00 – 16:30

Yoram Etzion (Ben-Gurion University): Leadless Pacing by Magnetic Actuation of Injected Iron-Microparticles

 

Free Evening or

17:00            

Guided walking tour of historic Freiburg (optional)

 

 

Saturday, 24 September 2016

Session 5: MEC & Arrhythmias: Animal Models 

Chair: Larissa Fabritz (University of Birmingham) 

09:00 – 09:30

Alex Quinn (Halifax): Mechanically-Induced Ventricular Ectopy and Fibrillation in the Isolated Heart

09:30 – 10:00

Ruben Coronel (Amsterdam): Synchronization of repolarization by mechano-electrical coupling in the heart

10:00 – 10:30

David Filgueiras-Rama (Madrid): Increased intraventricular pressure favouring sustained re-entry in the swine heart 

 

Coffee and Posters

11:00 – 11:30

José A. Barrabés (Barcelona): Stretch-activated channel block: effects on cardiac electrophysiology ex- and in-situ

11:30 – 12:00

Fanny Vaillant (Bordeaux): The isolated working porcine heart model for the study of mechanical, electrophysiological and metabolic functions.​

 

Lunch and Posters

Session 6: MEC & Arrhythmias in Human 

Chair: Michael R. Franz (Washington)

13:30 – 14:00

Dennis Lau (Adelaide): Acute atrial stretch and pulmonary vein arrhythmogenesis

14:00 – 14:30

Cathrin Theis (Mainz): Percutaneous Mitral Valve Repair and Ventricular Arrhythmias

14:30 – 15:00

Teri Whitman (Minneapolis): Influence of intracardiac pressure on spontaneous ventricular arrhythmias: lessons from the REDUCEhf trial

 

Tea and Posters

Closing Session

Chair: Peter Kohl (Freiburg)

15:15 – 15:30

Mark Marshall (Medtronic): What we’ve learned

15:30 – 15:45

Natalia Trayanova (Baltimore): Where we go from here

15:45 – 16:00

Discussion, Participant feedback

 

Meeting Dinner and Dance at Peterhofkeller

17:30

Reception 

18:00

Dinner

19:30 – 00:00

Entertainment

 

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