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Thursday, 12 September 2013

13:00-18:00

Registration (Sherrington Building, Department of Physiology, Anatomy and Genetics)

Trajectories in Science: a special session for PhD students and early-career researchers

Chairs: Veronique Meijborg and Alex Quinn (Sherrington Room)

15:00-15:30

Jeffrey Holmes

Do the job you want, even if it’s not the job you get

15:30-16:00

Frank Sachse

The ups and downs of an academic in the USA

16:00-16:15

Coffee break

16:15-16:45

Mark Marshall

Medical industry: the Dark Side of science is not so dark after all

16:45-17:15

Larissa Fabritz

Projects, patients, parenthood and perseverance

17:15-17:30

Wrap up

 

17:30-18:00

Drinks, nibbles and conversation

Keynote lecture: The Imperial College BHF Centre of Research Excellence Lecture

Chair: Peter Kohl (Sherrington Building Large Lecture Theatre)

18:00-19:00

Roger D Kamm

Engineered contractile tissue and its application in biological machines

19:30 -

Welcome Reception (Worcester College)

Friday, 13 September 2013

Session 1: Sub-cellular mechano-sensitivity (OeRC, Keble Road)

Chair: Pieter de Tombe

09:00-09:30

Bertrand Coste

Piezo channels: structure and function

09:30-10:00

Gentaro Iribe

Non-sarcolemmal stretch-activated channels

10:00-10:30

Stefan Dhein

Stretch effects on cardiac gap junctions

10:30-11:00

Coffee break

11:00-11:30

Matthias Gautel

MLCK’s: coupling strain to enzyme activity

11:30-12:00

Motohiro Nishida

Role of TRPC channels in mechano-chemo transduction in the heart

12:00-12:15

Workshop photograph

12:15-13:00

Lunch break (with poster preview)

Session 2: Cellular mechano-sensitivity

Chair: Michiel Janse

13:30-14:00

Dayue Darrel Duan

CLC-3 chloride channels in cardiovascular disease

14:00-14:30

Jeffery Molkentin

Accelerating Ca2+ removal from the sarcomere causes eccentric cardiac hypertrophy

14:30-15:00

Leslie Tung

Stretch, fibroblasts, and cardiac conduction

15:00-15:30

Coffee break

15:30-16:00

Arthur Beyder & Gianrico Farrugia

Voltage-gated sodium selective ion channel Nav1.5 mechanosensitivity is modulated by ranolazine and membrane-permeable local anesthetics

16:00-16:30

Christian Bollensdorff

Mechano-electric coupling effects on drugs: apelin

Session 3: Poster session

16:30-18:30

Posters (with drinks and nibbles)

Saturday, 14 September 2013

Session 4: New tools to study mechano-electric interactions

Chair: Gary Mirams

09:00-09:30

Michele Miragoli

Nano-scale sarcolemmal mechanical modulation

09:30-10:00

Fred Sachs

Measuring forces in proteins in live cells

10:00-10:30

Jan Huisken

Visualising and manipulating the zebrafish heart

10:30-11:00

Coffee break

11:00-11:30

Thomas Eschenhagen

Physiological cardiac tissue engineering

11:30-12:00

Roozbeh Ghaffari

High density mapping of complex arrhythmias using passive and active electronics onboard catheters

12:00-13:15

Lunch break (posters on display)

Session 5: Integration of M-E interactions: multi-cellular

Chair: Ruben Coronel

13:15-13:45

David Sedmera

Effects of mechanical loading on early conduction system differentiation

13:45-14:15

Jeff Omens

Regional activation and ventricular function

14:15-14:45

Jeffrey Holmes

Scars, stretch, structure, significance

14:45-15:15

Coffee break

 

15:15-15:45

Henk ter Keurs

Propagated contractions in rat cardiac trabeculae: effects of SR properties

15:45-16:15

Seiryo Sugiura

Structural heterogeneity in the ventricular wall may constitute the substrates for the stretch-induced arrhythmias in rabbit ventricles

Keynote lecture: The Hamamatsu Photonics Lecture

Chair: Max Lab

16:30-17:30

Jan Lammerding

Mechano-sensing from micro to nano: getting to the nucleus of the matter…

18:30-19:00

Pre-dinner drinks (Worcester College)

19:00-21:00

Dinner (Worcester College Hall)

21:00 -

Raising the bar… (music and drinks, Worcester College cellar bar)

Sunday, 14 September 2013

Session 6: Animal models of cardiac mechano-electric interactions

Chair: Ed White

09:30-10:00

Mark Link

Commotio cordis: ventricular fibrillation triggered by chest impact induced abnormalities in repolarization

10:00-10:30

Alex Quinn

Epicardial impacts and heart rhythm

10:30-11:00

Coffee break

11:00-11:30

Dan Adam

Extracorporeal acute cardiac pacing by high intensity focused ultrasound

11:30-12:00

David Saint

Animal models: stretch and ventricular arrhythmias

12:00-13:00

Lunch break (posters on display)

Session 7: Cardiac mechano-electrical interactions: clinical relevance

Chair: Michael Franz

13:00-13:30

Ulrich Schotten

Stretch and atrial arrhythmias

13:30-14:00

Flavia Ravelli

Atrial overload and arrhythmias in man

14:00-14:30

Peter Taggart

Mechano-electric coupling and the ECG

14:30-15:00

Coffee break

Plenary discussion: what next?

Chair: Peter Kohl

15:00-15:15

Ursula Ravens

Mechano-electric interactions: what have we learnt in the past 50 years, what do we need to do in the next five?

15:15-16:00

Plenary discussion: what next?

16:00-16:15

Meeting close

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